San Angelo is home to the corporate offices of Texas-Pacifico Transportation, Ltd., the operator of the 390 mile short line railroad that connects to the major railroads at its east end (including BNSF and the KCS and UP by way of the FWWR), interchanges with the UP at Alpine, and connects to the Mexican railroad network at its west end at Presidio, Texas/Ojinaga, Chihuahua. The railroad currently serves customers in the communities of Ballinger, Miles, Harriet, San Angelo, Mertzon, Barnhart, Big Lake, Rankin, McCamey, Sulphur Junction, Fort Stockton and Alpine. Main commodities moving on the TXPF include frac sand, crude oil, grain, and steel.
The Presidio-Ojinaga International Bridge is set to reopen in September 2019, reopening an important gateway that will expedite freight movement between the Dallas/Fort Worth area and north central Mexico and its Pacific coast ports.